– by Dr. Roy Farfara
Dr. Roy Farfara founded TrioxNano in 2015 with the intention to improve current medical treatments by benefiting from the vast potential of DNA nanotechnology. TrioxNano specializes in utilizing DNA nanotechnology in the fields of oncology and infectious disease. In this article he shares his views on DNA nanotechnology a field that he believes is the next technological health revolution. Most people are aware that DNA is the primordial genesis molecule coding the genetics of all life, yet only little are aware of its infinite potential to humanity in various sectors such as nanomedicine, biotechnology, biophysics, and computer science.
DNA’s ability to create life and potential in nanotechnology is based on the following characteristics:
- DNA is a relatively a stable molecule (we still find DNA from dinosaurs).
- DNA bases can create long chains (a chromosome is millions of bases long).
- DNA has a 4 letter coding (A, C, G, T).
- DNA bases are very small measuring less than 1 nanometer (one divided by one billion of a meter)
- DNA has a base pairing interaction, it’s a “2 bit magnetic trait” it creates bonds between two or more strains, so that the base A is always linked to the base T and the letter G is linked to the base C (and vice versa).
These 5 basic traits offer tremendous powers to those creators utilizing it to build things as will be depicted in the following article. By the year 2020 the scientific community is utilizing DNA store information (It is believed that DNA can store all the world data in a few rooms), build nanoscale machines to lift sort recognize materials. Such applications include TrioxNano’s DNA based infectious treatments, a drug delivery platform that can be programmed by the treating physician to the specific mutations in the patient’s cancer as well as many other solutions. DNA is enabling the fabrication of increasingly sophisticated nanostructures. This manufacturing approach is fully programmable and reproducible as it relies on the accurate specificity of DNA base–pairing interactions. DNA sequences can therefore be rationally designed to self-assemble into constructs of well defined dimensions, tailored shapes, and versatile functionality.
Examples of DNA based nano technologies follow:
- T.N.B Triox Nano Biotics. Is a nanotechnology that binds viruses to each other creating large aggregates that inhibit the virus ability to infect the human cells due to the aggregates size. The advantage of the platform compared to other treatments is that it only requires one binding site per pathogen to exert its action compared to a medicine needed to block infection that requires higher that 95% blockage to be useful. The platform is modular and can be programmed to different pathogen epitopes. This technology has been tried on Covid19 cell based assay and showed preliminary results of up to 80% inhibition of infection. It is currently being optimized to reach higher efficacy and tested for safety followed by clinical trials.
T.N.C Triox Nano Caps are specially designed nano carriers that can be adopted to carry different medication and be programmed at the point of care (treating physician) to the specifics of each patient’s pathology for example in the case of Triple Negative breast cancer according to BRCA, PD1, AS1141 positivity or levels of metabolites such as ATP, Zinc and Magnesium. Triox nano capsules offer substantial improvement over free chemotherapies in terms of efficacy and toxicity showing effects similar effect using only 1/100 of the original free chemotherapy dose in different human TNBC cells.
Dr. Farfara “DNA is the primordial molecule of life for the logical reasons explained above, I believe it is one of the most valuable tools offered to humanity to treat diseases. I foresee that DNA based nanotechnology treatments options are just around the corner (5-10 years). Examples for such technologies include TrioxNano’s programmable self assembling nanocapsules (TNC) and treatments for viruses like the Covid19 pandemic.
About the Author
Dr. Roy Farfara is a serial entrepreneur and innovator in the field of DNA nanotechnology. He specializes in utilizing DNA machinery to develop programmable treatment solutions. Among his inventions are self assembled programmable nanocapsules that can spontaneously capsulate many therapeutic molecules and a novel technology for the treatment of viruses such as Covid-19 that inhibits their infection. He is founder of TrioxNano a leading company in the field of programmable DNA nanotechnology.
